Welcome to 490 BioTech

490 BioTech is the only company that offers substrate-free bioluminescent human cell lines capable of continuously and autonomously producing light. This revolutionary new approach to optical imaging provides you with increased data acquisition in both tissues and small animal models. By taking advantage of our continuously light producing human cell lines it has finally become possible to break free from the expensive and error prone introduction of substrate and get back to doing what you do best – getting data.

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In Vitro Imaging

490 BioTech’s continuously bioluminescent cells are perfect for high throughput applications where the use of a luciferin requiring cell line would be cost prohibitive or where sample destruction would prevent repetitive data acquisition. Shown here in a 384 well format, our cells can be used across a wide variety of assay designs to suit your unique needs.

In Vivo Imaging

Keep your animals and your IACUC happy by switching to continuously bioluminescent cells. The bioluminescence from 490 BioTech’s cell lines can be imaged through tissue, allowing you to perform small animal studies without the repeated needle sticks required from luciferin induced systems.

The Scientist Top 10 Award

490 BioTech would like to thank The Scientist Magazine for recognizing our humanized bacterial luciferase as a Top 10 Innovation.

Visit The Scientist for more information.

NC3Rs Recognition

490 BioTech is honored to be recognized by the National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) as a novel technology for reducing animal use and improving animal welfare. Visit the NC3Rs blog for more information.

Join the substrate free revolution!

We have an ever growing consortium of scientists and engineers using our cell lines to advance their innovative R&D objectives. Please contact us if we can assist you in achieving your research goals.

  • St. Jude Children’s Research Hospital
  • The National Institutes of Health
  • The Ohio State University
  • Laboratoire d’Ingénierie des Systèmes Biologiques et des Procédés (LISBP), France
  • University of New Haven
  • Momenta Pharmaceuticals
  • The Koch Institute for Integrative Cancer Research, MIT
  • John B. Pierce Laboratory, Yale University
  • Aalborg University, Denmark
  • Johns Hopkins University Medical School
  • The Rockefeller University
  • Oak Ridge National Laboratory
  • The University of Tennessee
  • Beth Israel Deaconess Medical Center
  • Massachusetts General Hospital
  • Riken Center for Developmental Biology, Japan
  • University of Ouro Preto, Brazil
  • Kiyatec, Inc.
  • University College, London
Ohio State
St. Judes
John Hopkins